Our Research

HPC Principal Investigators are outstanding scientists with a proven track record in their respective fields and the ambition to make a difference in biomedicine, harnessing engineering and informatics tools. They are interdisciplinary by nature, highly collaborative, and committed to drive a globally competitive research program.


HPC scientists work towards a comprehensive and systems-level understanding of human physiology to revolutionize future diagnostics and therapies.


HPC scientists employ modern bioengineering principles and aim to develop new techniques and tools for trail-blazing applications in biological systems.

Biomedical AI

HPC scientists embrace information technologies to transform biomedical discovery and empower a revolution in healthcare.

Pioneer Campus Podcast Series

With the Helmholtz Pioneer Campus, HelmholtzMunich established a global talent hub and innovation campus – for the development of novel solutions that make a difference in the prevention, diagnosis and treatment of diseases. Our podcast hence provides a forum for established & future biomedical entrepreneurs, aimed at crystallizing some of the ‚secret ingredients‘ for rapid and successful knowledge translation toward societal benefit. Enjoy and regularly check back, as we develop this global series – leading up to our international BioEngineering 2024 conference (May 6/7th) in our brand-new PioneerCampus building.

Episode 3: “The Health Engineers”
Conversations with Vasilis Ntziachristos, Janna Nawroth, and Nimmi Ramanujam

Helmholtz Pioneer Campus researchers Vasilis Ntziachristos and Janna Nawroth represent complementary branches of bioengineering: Nawroth mines basic research on the structure & function of organisms to develop novel technology; Ntziachristos applies his engineering know-how and approaches to create new solutions for biomedical problems. We also spoke with Duke University’s Nimmi Ramanujam about bringing bioengineering advances to bear on the needs of marginalized or economically disadvantaged communities. All three researchers gave their perspectives on recruiting and training the next generation of bioengineers.

Produced by Thiago Carvalho.

Audio editor Marco Antonio/366 Ideas.

Episode 1: “Obesity is a brain disease.”
A conversation with Matthias Tschöp.

Mathias Tschöp is a physician, a scientist, and the Chief Executive Officer of Helmholtz Munich. Tschöp is the rare scientist who can look back on a road that started with basic research in mice and led up to new therapies for patients, revolutionizing the treatment of obesity.

Produced by Thiago Carvalho.

Audio editor Marco Antonio/366. 

also available on Spotify

Episode 4: "Biomedical AI: from data to meaning"
Conversations with Fabian Theis, Paolo Casale, and Mihaela van der Schaar.

Helmholtz Pioneer Campus researchers Fabian Theis and Paolo Casale discuss how Artificial Intelligence and Machine Learning are changing biology and medicine. The emerging computational tools are undeniably valuable in organizing the vast amounts of data modern Biology generates – and predicting outcomes with an accuracy that often surpassess human experts. But can AI also help us understand biological processes? Cambridge University Professor Mihaela van der Schaar gives her perspective on the interpretability problem; she also talked about how we can make the field more inclusive and the importance of collaborating with researchers outside of traditional STEM disciplines. It’s biomedical AI, from clinical diagnostics and cell atlases to a new understanding of biology and disease.

Episode 2: "Cell identity is generated from the epigenetic interpretation of the genome.”
Conversations with Maria Elena Torres-Padilla, Boyan Bonev and Wolf Reik.

Helmholtz Pioneer Campus researchers Maria Elena Torres-Padilla and Boyan Bonev discuss how the organism uses the same epigenetic toolkit to perform tasks as diverse as maintaining the totipotency of stem cells and differentiating cortical neurons. Wolf Reik discovered some of the first molecular mechanisms responsible for epigenetic imprinting of the genome. 

Produced by Thiago Carvalho.

Audio editor Marco Antonio/366 Ideas.